Monday, September 6, 2010

Combining Ketamine With Astrocytic Inhibitor

Astrocytes
Well, I know how hard it is for me to go without news about ketamine.  It's been a few days since I last spoke of this panacea, this club drug gone antidepressant, this animal tranquilizer deemed curative for CRPS/RSD.

It's going to take a lot of research, duplicated, peer-reviewed, and sanctified, thrice, by a Comprehensive and Integral Ad Hoc Committee Assembled by the Creator of the Universe, for me to get on the Ketamine Bandwagon. 

It could happen.

Today's offering comes from a group of scientists from the K. K. Leung Brain Research Centre of the Fourth Military Medical University in Xi’an, China, and is published in Molecular Pain.  The authors come from the Departments of Anesthesiology and Anatomy. 

The folks hailing from Anesthesiology are further specialized as "stomatologists." "Ewww!" was my first thought, closely followed by curiosity about CRPS of one's stoma... but it turns out that stomatology is the study of the mouth and its diseases:  dentistry, in other words!  I guess an anesthesiologist/stomatologist represents -- in Western formulations -- someone with a DDS who has done post-graduate work in anesthesiology.  What it means in the Chinese context, I dunno.  Perhaps it includes acupuncture.

That there is a décalage between Western Dentistry and Chinese Stomatology is clear:  For instance, like the American Dental Association, the Chinese Stomalogical Association declared that fluoride toothpaste helps prevent tooth decay... but C.S.A. did it in 2007.  I guess the actual availability of fluoridation plays a big part in that evolution, and further realize that the issue of fluoridation is not as clear cut to some as it is to me.  If you believe that fluoride causes cancer, then the topic of fluoride in your communal water supply is not a lighthearted topic.  [Okay, moving right along... don't wanna get lost... too late?  Is it too late?]

Rather quickly, I am wondering about the quality of translation in this work.  The current PDF version at Molecular Pain is provisional, with a promise of a fully formatted/full text version to be available soon.  I hope that can include scrutiny of translation from Chinese to English.  For instance, I am sure this sentence can be improved upon:

However, the present clinical therapeutics is still just concerning about neuronal participation.

And just because, I would like one of the authors to expound upon this:

Combined administration obviously relieved mechanical allodynia in a quick and stable manner.  [How?!  How did they know?!  I mean, my assumption is that we're talking lab rats here...  Was it that deep sigh of relief?  The fading furrows on the brow?  That certain sassy swish to the tail?]


Hmmm?  The claim?  The object of the study?  Jeez, but You Readers are demanding.  Is that a Burgeoning Sense of Entitlement rearing its ugly little head? 

Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain

Molecular Pain 2010, 6:50   doi:10.1186/1744-8069-6-50

Published: 6 September 2010



ABSTRACT
Background: Neuropathic pain is an intractable clinical problem. Intrathecal ketamine, a
noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to be useful for
treating neuropathic pain in clinic by inhibiting the activity of spinal neurons. Nevertheless,
emerging studies have disclosed that spinal astrocytes played a critical role in the initiation and
maintenance of neuropathic pain. However, the present clinical therapeutics is still just concerning
about neuronal participation. Therefore, the present study is to validate the coadministration
effects of a neuronal noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist
ketamine and astrocytic cytotoxin L-α-aminoadipate (LAA) on spinal nerve ligation
(SNL)-induced neuropathic pain.

Results: Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated
SNL-induced mechanical allodynia in a dose-dependent manner respectively. Phosphorylated NR1
(pNR1) or glial fibrillary acidic protein (GFAP) expression was down-regulated by intrathecal
ketamine (100, 1000 μg/kg) or LAA (50, 100 nmol) respectively. The combination of ketamine
(100 μg/kg) with LAA (50 nmol) showed superadditive effects on neuropathic pain compared with
that of intrathecal administration of either ketamine or LAA alone. Combined administration
obviously relieved mechanical allodynia in a quick and stable manner. Moreover, down-regulation
of pNR1 and GFAP expression were also enhanced by drugs coadministration.

Conclusions: These results suggest that combining NMDAR antagonist ketamine with an
astrocytic inhibitor or cytotoxin, which is suitable for clinical use once synthesized, might be a
potential strategy for clinical management of neuropathic pain.

Direct Correspondance to:

Dr. Li-Xian Xu at
Department of Anesthesiology, School of Stomatology
Fourth Military Medical University, Xi’an, 710032, China
Tel: 86-29-84776115 Fax: 86-29-84776115 E-mail: kqmzk@126.com

Dr. Sheng-Xi Wu at
Department of Anatomy, Histology and embryology; K.K. Leung Brain Research Centre, Fourth
Military Medical University, Xi’an 710032, China
Tel: 86-29-84773074 E-mail: shengxi@fmmu.edu.cn

Dr. Yun-Qing Li at
Department of Anatomy, histology and embryology, K. K. Leung Brain Research Centre, Fourth
Military Medical University, Xi’an, 710032, China
Tel: 86-29-84774501 E-mail: deptanat@fmmu.edu.cn

ABOUT MOLECULAR PAIN:

Molecular Pain is an open access, peer-reviewed, online journal that encompasses pain research at the cellular, subcellular and molecularlevels.

Molecular pain is a growing research field that represents an advanced step from conventional pain research, addressing physiological and pathological pain at the cellular, subcellular and molecular levels.

Molecular pain research integrates pain research with molecular biology, genomics, proteomics, modern electrophysiology and neurobiology. The field of molecular pain research has great promise for the identification of highly specific and effective targets for the treatment of intractable pain.

Sunday, September 5, 2010

The Taiji Slaughter Set to Begin, Again

The photo above has NOT been ‘Photoshopped’ – that is the actual color of the water due to the annual slaughter of tens of thousands of dolphins in a secluded cove in TAIJI, Japan. You can see several of the killed dolphins in the boat. That’s all blood – a sea of blood.


The coastal village of Taiji, Japan, is home to the worst dolphin massacres in the world, motivated entirely by greed and fueled by the ignorance of the local people and the Japanese government. The bloody red waters of Taiji, Japan are only the beginning of this story...

From blog Taiji, Japan


If you've not seen the documentary The Cove, you should. 

La Bonne et Belle Bianca rented it, by mistake, one hot summer night last year.  It was Movie Night at The Manor, just a little something we do on behalf of Management and Domestic Staff Relations -- to bring everyone a little closer, build a little camaraderie.

It was the last hot day of ManorFest 2009. We were inundated with Monks taking advantage of Last Day Specials -- especially the discount to Walk the Labyrinth.  The sun was setting and there were still some 55 Cistercians wandering around the Marlinspike Manor Maze, which they consider a spiritual exercise.  The Brothers who had already found their way out lined the rear arc of the amphitheater, killing time with a movie while their colleagues quietly cursed the falling darkness inside the serpentine boxwood.

(Our Rescue Teams would lead them out during Intermission.)

The Castafiore thought she had snagged a film of The Kooks in concert and -- given the amazing way in which sound carries in our open-air stadium -- disrupted the first ten minutes of The Cove with Fierce Mutterings:  Oh! Dieu, que de bijoux-oux-oux!  Ah... ah... ah... je ris de me voir-r-r si belle en ce miroir-r-r!

Kind of hard to ignore, I admit, but we've had years of practice.

Eventually, even Bianca was drawn into the strange world of Taiji, Japan, and its accusatory eyes and barely concealed evil.  The Monks would have heaved Big Sighs, if that were allowed.  Those moments when Prayerful Intercession runs smak dab into Active Need are hard to reconcile.

That's not to say that this movie's Call to Action fell on completely deaf (or tonsured) ears.  A good many emails went out, righteously indignant.  None were answered, and there were no second volleys of indignation on our part.

It's easier just to forget.

But we've ordered time so that it cycles for many reasons, one of which is annual remembrance, recurrence.  Yesterday, I read:


These are dark days in Taiji, Japan, as far as conservationists are concerned, because this week marks the beginning of the annual dolphin hunt in the remote village made famous last year by the Academy Award-winning documentary, "The Cove."

The hunt began Wednesday despite widespread international opposition and protests in Tokyo.

Ric O'Barry, who trained dolphins for the 1960s show "Flipper" and helped produce "The Cove," traveled to Tokyo and delivered a petition of opposition, signed by 1.7 million people from 155 countries, to the U.S. Embassy. The activist, who also has produced an Animal Planet miniseries called "Blood Dolphins," was forced to cancel a trip to Taiji amid alleged threats from an ultra-nationalist group.

"I wish all these people could be in Taiji," O'Barry told The Associated Press. "It was too dangerous. The big losers are the people of Taiji."

Most of the dolphins corralled into the cove during the hunts are killed and processed for meat, but some specimens are sold live to aquariums. Japan allows the killing of about 20,000 dolphins a year and claims the hunts are an important part of the nation's culture and tradition.

Taiji, a community of about 3,500 and the birthplace of Japanese whaling, accounts for about 1,500 dolphin deaths annually. Its "oikomi hunting" practice of banging on metal poles to create a wall of sound to herd dolphins into the cove in preparation for slaughter is what drew worldwide criticism after "The Cove" was released.

"We will pass down the history of our ancestors to the next generation, preserve it. We have a strong sense of pride about this," town Mayor Kazutaka Sangen told the AP. "So we are not going to change our plans for the town based on the criticism of foreigners."

The first victims, about 20 bottlenose dolphins, were herded into the infamous cove on Thursday. The cove, with the help of netting, will serve as a holding pen. The actual killing of dolphins won't begin for about two weeks...
-- Despite swelling opposition, dolphin hunt begins in Taiji, Japan
By Pete Thomas, GrindTV.com
Friday, September 3, 2010 9:33am PDT

This video about the dolphin killing in Taiji was made by BlueVoice.org in late 2006:

Saturday, September 4, 2010

Kirsten of Christchurch

Blogger Kirsten of Christchurch, New Zealand, just got home after major surgery, ready to rest up and begin a great recovery.

Major Surgery?  Meet Major Earthquake.

AP Press reports:
Buildings collapse, 2 injured in powerful NZ quake
By ROB GRIFFITH, Associated Press Writer

CHRISTCHURCH, New Zealand – Chimneys and walls crumbled to the ground, roads cracked in half and residents were knocked off their feet as a powerful magnitude-7.1 earthquake rocked New Zealand's South Island early Saturday. The prime minister said it was a miracle no one was killed.

Only two serious injuries were reported from the quake, which shook thousands of people awake when it struck at 4:35 a.m. near the southern city of Christchurch. There were reports of some people trapped inside damaged buildings — though none appeared to be crushed by rubble — and a few looters broke into some damaged shops in the city of 400,000.

Power was cut across the region, roads were blocked by debris, and gas and water supplies were disrupted, Christchurch Mayor Bob Parker said. Chimneys and walls of older buildings were reduced to rubble, and Parker warned that continuing aftershocks could cause masonry to fall from damaged buildings... [continued here]

Kirsten's blog, Urinary Diversions, formerly Neo-Conduit, is an interesting mix of information, both personal and abstracted, about surgical urinary diversions, as well as her frustrating experiences with the medical system in New Zealand. She is an activist on behalf of patient rights, women's rights, and has a love affair, too, with fuzzy, furry domesticated animals.

So, yes, she just got home after a big surgery, after which she had some complications and was in clear need of rest and relaxation. At least she had a few quiet days before Mother Nature made the earth tremble.

She went for a walk with her daughter, in search of bottled water, and posted some photos of the damage in her neighborhood. Go take a look!

Thursday, September 2, 2010

Shawnna's Con

Editorial reflection:

I wrote this post on January 24, 2009. That is neither here, nor there, but was, it happens, a significant date. That is my birthday.

This tells me, and I am telling you, in turn, that the circumstances in the post must have been very upsetting. This is not the kind of thing about which one wants to be thinking on one's birthday.

Today, having an additional 20 months of riotous living under my belt, I know that the story I am about to tell is not at all unusual. That's terribly sad, but is, as they say, what it is.

You cannot and should not trust that anyone is who they say they are, is how they claim to be. Unless, of course, you have the means to verify stuff. Unless, of course, you just don't care. Unless, of course, you are one of those people who are brimming-to-overflow with forgiveness.

To update "Shawnna's Con," her latest claims are that she is awaiting a heart transplant, that she had a stroke on Easter Sunday, that her HIV+ daughter is now having her fourth child since diagnosis, and that she, Shawnna, is raising three of those children, that she never made it to Tennessee, but remains in North Carolina. (Note to Self: There seems to be an inordinate number of internet shysters residing in North Carolina. I love N.C. -- I lived there when I was in high school, taught and studied at Duke, and have a long love affair with Atlantic Beach/Morehead City -- so it pains me to say this.)

I decided to use my subscription to an information agency again -- the last time I used it was to discover that my half-siblings, newly admitted into my life, had quite the criminal record. Guess where they live? And before that, it was to discover the deviant goings-on with my cyber-stalker... Who, I kid you not, lives about a half-hour from my sterling half-relatives! What a state!

People with criminal records don't necessarily end up on some sort of exclusionary list of mine. Gauging from the dates of arrest, it looks like my sibs went through a very hellish period, during which they may have been trying to establish some kind of financial independence from The Mother-Unit, although they benefited from having an absolute saint for a father. My Mother is, as the saying goes, a piece of work. Had they ended up hardened felons, incontinent of urine and stool, with needles hanging out of their arms, and their hair all mussed -- I would have understood.

Even my cyberstalker's legal troubles are understandable, stemming as they do from terrible poverty, and, I think, a terrible lack of decent role models and self-esteem. Unfortunately, her daughters now have records, too, for the same reasons. It is a sign of hope, though, that they must suck at thieving, for they've all been caught.

"Shawnna," however, is a con artist and seems to enjoy reeling people in on her fishy lines of drama, trauma. She invades your heart, heartlessly. She has a substantial area dedicated to her crimes on the N.C. Master List of Master Criminals, one arrest coming on the same date of her last claimed thrust-and-parry with Death -- Easter Sunday ("They had to Life Flight me..."). 

Resurrection Jealousy.

I can find no proof online that her recently deceased husband ever existed. Nonetheless, his name has been altered, as well as hers.

The fact that every "disturbed" person I've encountered were met over at the Dr. Phil website is just something I present to you, without commentary. {Though you should see my eyebrows wiggle...}

Hard luck stories are the bread-and-butter of the con, I guess. And I may as well confess, not for the first time here, that I am the World's Easiest Mark. It is great sport among my family and friends to see just how much junk they can get me to believe. I melt at a low temperature, cooing "Oh no, really?" upon hearing their sad, sad sagas.

But I think I am wising up! At least with Fred. He has some "tells" that I can now identify, chief among which is the statement: "This is a true story." But, oh, how it delights him when he can reel me in. I am not going to embarrass myself by laying out the far fetched things I have come to accept as true -- but I recently made mention of one, so I'll reuse it. My former bestest friend in the whole wide world is a gorgeous Iranienne Lesbian (but not, praise Jesus, one of the Militant Lesbian Existentialist Feminists). We met as undergrads, roomed together for a while, and -- even though I screwed up our relationship in recent years -- had a wonderful life together. She just could not believe the extent of my gullibility. One day, we were working on homework in the French Dept. lounge, trying to come up with paper topics for our 17th century lit class. She hit on something she thought I would like -- having to do with that famous classicist Oussama Mon Chénier.

Chenier is a Cajun term, referencing a:
beach ridge, usually composed of sand-sized material resting on clay or mud. Chenier is the Louisiana French term for the oak tree belts that mark the distribution of the ridges in the Mississippi Delta region. In that area there are several sets of cheniers, each separated from, and slightly unconformable to, the next. Some of the ridges have been reworked by waves, and several show a blanket of peat growth (indicating a regression of sea level) covered by marine sediments. The arrangement and composition of these cheniers are taken as evidence of a fluctuation in sea level and have been correlated in time with similar evidence in other areas of the world. (from Britannica.com)

The Shah-Meister regaled me with fond memories of her relationship with this 17th century naturalist, and how she spent many a rainy afternoon stretched out on her bed, thumbing through his great and marvelously illustrated work:  L'Histoire Naturelle des Animaux Sauvages (The Natural History of Wild Animals).  She had never understood why it was such a beloved reference work in Persia but unknown to Unenlightened Westerners.

By the time she convinced me to go and interrogate Professor Aronson là-dessus, I was frothing at the mouth at the thought of the academic wealth awaiting my investigation.  I will just let you imagine my horror at the kindly sad smile which my respected professor assumed about 10 seconds into my presentation of my awesome paper topic...

And then there was the Incident on the Berkeley Pier.

But "Shawnna"?  She's on a whole other level of malevolence.  Given her recent re-emergence (we surmise that she may just have gotten released from prison), I decided to go ahead and post this.  Should you come upon it, Lashy?  I am a Born Again Skeptic, as well as Very Certain Friend to the Woman You Are Trying to Snooker.  So back the fuck up, woman.  I mean it.
***********************************************************************







It's beyond disconcerting: beyond it, though, to I don't exactly know what.

The popular initial reaction seems to be "disappointment." That surely was the killer reaction that worked best on me as a child -- nothing hurt so much as when a beloved adult would calmly (with maybe a Touch of Glum) express disappointment in me and in whatever behavior I had perpetrated.

For 18 months, this woman Shawnna interacted almost daily with me and several other people in an online group that dealt with the vagaries of living with chronic pain.

Oh, put your eyes back in your head! Stifle!

This group put up with *me*, remember. How much time do we spend talking about pain? Almost none. How much time do we spend bitching about doctors and tests and drugs and such, ka-ching? Okay, well, maybe 27% of our text might be so appropriated. Another 52% is dedicated to regaling one another with stories that sometimes tested the boundaries of decency. Roughly 20% of the time, we deal with people who will most likely not be sticking around to become a regular. They are panicked by passing discomforts, angry at the world, desperate for sympathy and compassion, and, occasionally, really in big trouble -- that's when we function like a well-oiled machine and produce names, numbers, web links, contacts, straight up info.

The remaining percentile? In-de-fin-able! That cachet of a certain je-ne-sais-quoi...

There is a woman in this group who keeps me sane. Her latest daily adventures include stealth feeding of two groups of horses that belong to her neighbors -- or, to be precise in one of the instances, the girlfriend of a neighbor who is billeting her horses there for the duration of the love affair. This friend is an animal lover, but not in the extreme -- these horses were not being fed daily and did not have access to [unfrozen] fresh water -- and I think she has reacted as most of us would. Well, not quite. I would be on the phone reporting these neighbors -- in a heartbeat. I do not, apparently, understand the dynamics of life in rural Wyoming, as such an act might well, she tells me, push her neighbors over sanity's edge... and then what would she do?

So, she does the only logical thing.

Excuse me while I laugh a little.

She and her 80-something mother take hay to the two separate pens. I don't know the story of the other neighbor. They wait for the cover of darkness and deliver hay and water. The horses apparently go ape shit every time they see either of the two women, or even their truck.

She has a good heart.

So I am going to go way past "disappointment" and charge on down the path all the way to ANGER. Not at her, no!

At the woman who has fooled her, and me, and lord knows how many others. We nicknamed her Shawnna. She was thrilled when she was given a nickname. It made her "one of us," one of the gang, party to the inner circle, whatever -- it marked the moment when she had definitively snookered us all.

I spent part of the day digging up every post she had ever published at the web site that hosted our laughter-loving chronic pain support group. Somehow, she never expected anyone to piece all the disparate parts together. Well, I got right to it, didn't I? It just took me a year and a half.

This is the story she has written, in bits and pieces, some meant for one group, some for another:

She is 43. She just recently lost the triplets she was carrying -- made it to 6+ months, though. There are several posts about her inability to go into the nursery and pack up the tiny clothes and take down the cribs, maybe throw a little paint on the walls, scrape those silly stencils off, try to sell that stupid rocking chair on eBay.

That was mostly for an online grief support group that rallied around her as she faced the anniversary of the triplets' death, and with whom she went on to share her childhood experiences of incest. Eventually, I guess, there was a strong sense of incongruity, and she moved on to the more appropriate Childhood Sexual Abuse Survivors Group, never speaking of the dead babies again.

About that same time, she approached us with a need for advice about having, or not having, a hysterectomy. The reason given was "pelvic pain." For reasons that I could never figure out, her surgery was supposed to take between 6-8 hours and might result in her death, or a colostomy. (Tonight, I relish that symmetry: her death or a colostomy. I like those odds.) She said she'd had 15 previous abdominal surgeries.

Let's see... She suffered from cardiomyopathy and a well-controlled seizure disorder, although she had a seizure on the operating table during her last operation and... you got it! Almost died.

"I almost died" could have been the chapter heading for most of her revelations.

She had three adult children. Her son was in prison for murder. Oh. As it happens, her brother was going on trial as a serial killer, and she lived in dread of having to testify. Her oldest daughter was a heroin addict with two small children. She popped into the narrative as a regular character when Shawnna decided she should have AIDS, abandon her kids (the long suffering Shawnna and her husband Rudy dedicated themselves to raising them, of course), and run off to New York with a no good man.

Shawnna's youngest daughter was a straight-A student, finishing her first year at college, and had never caused, or been in, any sort of trouble, ever. With the now added burden of two toddlers to raise, we suggested to Shawnna that her "good" daughter might be able to help out on the weekends. "Oh no," we were told, she did not want to be a burden to this young one who was doing so well.

Not even after her surgery went awry and she was mostly bedridden and living on methadone and percocet (Hey! I resemble that remark!) would she consider asking her daughter for help. She would carry on, somehow -- taking care of those two grandchildren, volunteering at their schools, working at the funeral parlor (part-time) and taking care of what she called her "wifely duties" with Rudy. [Prior to working at the funeral parlor, Shawnna said she owned a Home Health Agency, which she loved, as it allowed her to use her training as a *nurse*! I guess that is not an altogether uncommon move, to go from the healing arts to the death business?]

Of course Shawnna's surgery did not go well! This was surprising, as it took place at UNC-Chapel Hill (those slouches!). Would you believe that the numb nuts left a sponge inside of her? She ended up needing more surgeries because of their horrid oversight.

Then began the Saga of the Vaginal Bleeding. I know that it stretches the bounds of your credulity, but it was only at this point that she lost me as one of her dedicated cheerleaders. Because she kept bleeding and bleeding, going in and out of the hospital several times a week. I have also had a total hysterectomy and my crude understanding of anatomy informed me that there just are not that many sources for such bleeding... Somehow, I assuaged my suspicions with the reassurance that I apparently did not know everything, and that Shawnna was surely cursed and being used by God to do a rewrite of the Book of Job.

(Book, shmuck! I forgot to mention that she is an author of two books. No, I haven't been able to find either one.)

Oh, I grow weary.

Well, what is left to Shawnna's Tale? Ah, yes. Rudy almost passed away about a year ago -- he had a major stroke at the age of 33. He up and died a month or so ago -- he was out mowing the lawn and had a massive heart attack.

My tenderhearted Wyoming friend prepared herself for service -- a plane ticket, her own home and hearth in order -- and waited for details. Waited and waited. Shawnna was impossible to reach.

Suddenly, she posted a message saying that she was going to relocate to Memphis, Tennessee. I had begun searching for a death notice, checking obituaries in her area, then anywhere, then under any mistaken spelling of the poor dead man's last name. Nothing, nada, zilch. I asked her about it, finally, and was told that her world was turned upside down (understandable) and that Rudy's adult son from a previous marriage was handling those details.

Okie-dokie, then!

After a bit, she reappeared, reintroducing herself this way in an email, afraid, it seems, that the various plots of her story might have become stale:


I know that it's been a very long time, I'm fine. I have 4 grandchildren now, and all by the same daughter. I have three of them. I had a stroke on this past Easter Sunday but I must say that with some physical, and speech therapy I'm doing much better, I have been missing both you and M but I almost lost my  mind girl after my husband passed away. I'm much better know, and I've learned to cope with it. I love you just the same as I did one year ago girl!

Love,
Lashy

Finally, a period of relative calm, with only occasional hospitalizations for congestive heart failure interrupting. She was off to her new life in Elvis Land.

Except that we heard nothing and could not reach her. Finally, we received a message that she had suffered a major heart attack while driving...

With a familiarity that suddenly *was* breeding a major pile of contempt, we could not contact her at the hospital she was supposedly at and so on and so on and so forth.  In the past, her "good daughter" would appear online at these times of crisis, and promise to relay messages, etc.  There appeared to even actually be such a daughter that my friends were able to reach by phone.  Something in that precious mother-daughter relationship became irrevocably strained at this point, however, because Lashy wrote, out of the peculiar blue:

She  is  doing well, she is studying at The University of Winston-Salem now. She is in her 5th year of schooling. She is still studyimg to become a Psychologist. But guess what? She doesn't even call me, come to see me. She didn't even come to the hospital after I had the stroke, and I had been life-flighted there to Winston-Salem!!!!! I was sooooo hurt. I just couldn't believe that she didn't come to see me. I haven't heard from her now in almost a year. I just this information from her father. But  I am not going to sit and worry about what is going on, I love her, have done not one thing for her to treat me the way she's been, and one day she'll regret the time that we didn't share together.

There is, of course, no University of Winston-Salem, so I assumed it a reference to Winston-Salem State University.  But it, of course, has no graduate program in psychology, but does have a good-looking undergraduate BA degree in the field.

It was a great set up.  Now Good-Daughter-Turned-Mean-Child could not be relied upon as a benevolent player in Shawnna Land.  You can't trust her or believe a word she says!

That fix was apparently not enough, however, because Shawnna went on to have Good-Daughter-Turned-Mean-Child suffer a stroke, herself, and be put, herself, on the "transplant list." Again, Lashy was kind enough to provide all sorts of contradictory written information, though she never seems to completely hoist her own petard.  This is a letter she sent to my good friend during Scene 4 of Act 3, or whatever we are to call this internet con drama.  It's one of her more elaborate, and the construction is interesting, particularly the opening gambit.  Hi, it's been forever, my dying-with-AIDS daughter is such a whore... my Good-Gone-Bad-Now-Redeemed-Again daughter is in ICU... all summed up by the telling, "Oh my God girl!!!! What more can I deal with huh?"

I don't know the requirements for receiving hospice care, but apparently they are not as stringent as I believed!


----- Original Message -----

Hey Girlie,
I know that it's been a while that we've spoken. How has everything been going for you? I have some very disturbing news. I just found out very recently that my last granddaughter is not my daughter's husband's daughter!!! No, her father is some other low-life piece of shit that roams the city of Fayetteville! The DNA test just came back last week. I am so through with my daughter do you hear me! So now we've got to try and find this someone to let him know that he is now a Father. I spoke with my daughter and asked her what the hell is she thinking? Not only were you unfaithful in your marriage but you had unprotected sex with someone that you really don't even know!!!! She tells me that she's been knowing this man for a year! Uh....wow...a whole year!. Please, give me a break!

Plus the fact that T (my youngest daughter) is in ICU and has been for the last past four days, we found out that she has inherited my cardiac condition. She has an enlarged heart and went out to the emergency after feeling very ill. She was having difficulties breathing and was having some swelling in her legs and hands. Oh my God girl!!!! What more can I deal with huh? But the good news is that she's doing better and the Physician told me that he'd be able to step her down off of the milirinone lactate and put her on an oral medication at this point. So hopefully she's be discharged at some point this coming week. 

I always feared one of my three children inheriting my cardiac condition and the one that has her shit together is the one that has been crippled with this enormous problem. I'm very afraid that this will limit her ability to have children one day when she's ready. All I can do is guide her and show her how to deal with this cardiac problem. They have put in a picc line so that she can be administered the milirinone, the same medication that I use on a continuous basis here at home. My picc line has been sewn in place though.

**[Lashy simultaneously posted elsewhere that Good Daughter Gone Bad was comatose, had had a stroke and suffered severe neurological deficits.  Milirinone (sic) lactate?!  Yowza!  In the little bit of reading I did about the drug, one thing was pretty doggone clear:  "treatment with this drug usually does not exceed 5 days..."  This archived drug label made it clear that this warning against longterm use was not lightly made:

Whether given orally or by continuous or intermittent intravenous infusion, milrinone has not been shown to be safe or effective in the longer (greater than 48 hours) treatment of patients with heart failure. In a multicenter trial of 1088 patients with Class III and IV heart failure, long-term oral treatment with milrinone was associated with no improvement in symptoms and an increased risk of hospitalization and death. In this study, patients with Class IV symptoms appeared to be at particular risk of life-threatening cardiovascular reactions. There is no evidence that milrinone given by long-term continuous or intermittent infusion does not carry a similar risk.]**


I was in the hospital for my birthday, (7th January). I was in CHF and renal failure. I am better now and hopefully I won't have another hospitalization for some time.

I allowed my daughter to come over to spend a few hours with all of the children during the holiday and she didn't even think or consider buying either child anything for the holiday! I was very disappointed in that too. I have just come to realize that my daughter will always be selfish, bottom line.
Have you talked with M lately? I would like to go and see her for my 1-week vacation this coming April once the kids are out for Spring-break but I haven't heard back from her to confirm. I would like to come see you one Spring/Summer as well.

I really miss you guys so much. I feel so bad sometimes girl that it takes all I have just to get up and move around each day. My cardiac health is slowly declining, and I can really feel the change. I have hospice coming in each day and they've helped me aloft as far pain relief, and making dr's appt's for me.  And I have a CNA to come out each day for three hours. She helps with laundry and running errands for me.
I just wish that I could feel 30% better.

I had a difficult time yet again this year during the holidays because as you remember Rudy passed on the 6th December. I must admit that having friends and family here for the holidays did distract from the depression that I was feeling but, It was still difficult and I guess that it will never really go away.
Well Sweetheart, I've taken up enough of your time with my whining so I just want to let you know that truly I love you very much and because I may not post or send messages as often as I did before, doesn't mean that you're not on my mind. I look forward in hearing from you soon....Talk later
Love,
Lashy
P.S Have you heard from Prof? If so, please give her my hello's.......................
[Prof, here, chuckling...]

Somewhere in all the chaos, Lashawnna began to mention LVADs, and it was never clear whether she had one, but it became something of an obsession, but -- as you might expect -- the LVAD stories came with their own healthy quantity of red flags.  Small flags, maybe more of a bled pink than a screaming ninny of a cerise.  Things like continued smoking, something that I'd think one might give up if faced with left ventricular failure.

I was contacted by a very nice guy who is an authority on LVADs and whose blog is dedicated to helping others learn about the life-saving devices.  Shawnna was driving him a bit mad, contacting him repeatedly with requests that he call her, and performing her typical zero-to-sixty insistence on intimacy.  You know what I mean!  She glosses over the normal periods of making acquaintances so as to rapidly insert herself and her confusions into the mark's life.  Unfortunately, she just came off sounding weird to him and he did an internet search... finding, eventually, "Shawnna's Con."

An aside:  What a wonderful guy, what a wonderful attitude!  He is steeped in gratitude, and it shows -- well beyond words, it shows in pictures and videos, it shows in how he reaches out to give others a hand up.

My capacity for playing the fool has amazed me. I still want the thousand dollars back that I gave to someone I "met" online in an osteonecrosis support group.  I did not hesitate to help her pay her electric bill so that the utility could be turned back on, keeping her young children warm. One of her sons was very ill, she said, and she couldn't afford to take him to the doctor.  Are you sitting down?  Turns out she had other uses in mind for my money, uses that were more in the line of "entertainment."  Well, we are all deserving of fun... Right?

I never gave Shawnna anything material.

No, I cried with her, listened, tried to help and advise, pitied and prayed for her -- and for "hers," who were always so deep into trouble, lost without her able help and guidance.

I cannot even laugh at myself as I begin to seriously fret over who is taking care of those beautiful, innocent grandkids.

Because I cannot know what tidbits are true, which are false, which are more properly interpretations.  She may have a failed heart, her daughters might be equally ill -- one sticken with Lashy's own disease, an inheritance, the other with AIDS, Lashy's emblem for "bad."

The proliferation of grandchildren, all born to an HIV+ woman, is at the heart of this con's tale.  Babies, some of them dead (her opening at Dr. Phil's, remember, was that she had just lost triplets), all of them displaced, are what's the matter.

I wish I understood.

It turns out, I believe, at least, that Shawnna has an accomplice. So I -- and others, especially one kind spirit in Wyoming -- are waiting for the other shoe to drop in the saga of Shawnna's con.  She wants to set a trap, and has, probably.  I just want to issue a Public Safety Announcement -- which is what I suppose this post was supposed to be.

But oh, Dear Readers, there was one wondrous development, just a few months ago, and I will end this rambling "cautionary tale" by copying below a rare moment of love and warmth between myself and this con artist.


You can imagine how thrilled I was to be able to notify Shawnna, in January 2012, that there had been a resurrection, good news of the miraculous sort:

lashawnna wrote: 
"Morgan and Dianah I know that it's been a while since I last spoke to either of you, I have been really having a hard time dealing with the death of my husband, so much so that I had to relocate to another home, too many memories.[...] Prof, I have really had you in my thoughts and prayers and I hope that all is well with you. I have had to really dig deep for my sanity, for a time there, the walls started to close in on me and I felt as if I was losing sight on reality. I couldn't sleep because I was in constant thought of Rudy. I have lost 39 pounds. When I first started posting, I wore a size 14 pants, now I am wearing a size 5/6."

i, profderien, wrote: 
hi lashy,
long time, girl, long time!
but i am so glad to be able to come to you with good news.  
heck, it's great news!  
are you sitting down?  no?  well, take a second and sit yourself down, because i don't want you to faint and hit your head, thereby sustaining a life-threatening subarachnoid hemorrhage or possibly fracturing the medial epicondyle of your humerus (the "funny bone"!).  heck, the joyful shock of what i am about to disclose to you, our dear loving lashy, might cause your cardiac muscle to shift into overdrive.
it's PHENOMENAL news!  it's put-it-on-the-doctor-phil-show-it's-so-good news!  (seriously, my friend, you would make a fascinating guest.)
ready?  are you sure?  okay, here goes:
RUDY IS ALIVE AND WELL AND WORKING AT WALMART!  It's a freaking miracle of humongous proportions.  
no, i am not pulling your tiny size 5/6 leg!  it's time to have a really big, fattening meal in celebration -- but cardiac-friendly, of course, maybe an arugula salad dressed with balsamic vinaigrette, some poached salmon over a lovely parsnip purée. (i'm hungry.)
you probably don't believe me, i know what a stickler you are for truth, justice, and the american way -- and here i am, saying rudy (by whose grave you wept and loss scads of weight) -- that scumbag who pretended to stroke out while mowing the lawn -- here i am saying that your husband rudy is flaunting his status as a living organism... all over facebook!
i wasn't sure, and again, out of respect for your reliance on honesty, i asked someone who knows what rudy looks like to take a gander at his profile picture.  i was assured that "yep, that's him!  the no-goog pretending-to-be-dead bozo!" 
i know, this news is really a mixed bag.  part pure relief (He Lives!) and part ultimate frustration (How Could He Let Me Grieve and Waste Away to a Size 5/6?).
but you are nothing if not a strong woman, accustomed to adversity (good lord, when i think of the tragedies your family has suffered... the loss of your triplets, your brother's murder conviction, your son's murder conviction, your daughter's HIV, your other daughter's cardiomyopathy, your own cardiomyopathy, your multiple and simultaneous needs for a heart transplant... why, it boggles the mind, if not one's credulity!).
i gotta say, though, lashy... i believe i would divorce the bastard.  no doubt you have moved on in these intervening years, and some other lucky man has scooped you up.
well, that's about all.  i hope you can get over the shock of it.  this is a great place to vent, though, you know?  everyone here is like FAMILY, gullible as all get out, willing to lend you sympathy, understanding, love, and probably a ten spot or two.  you can say *anything* here.  it's a safe place, where no one trolls for victims to exploit, where no one even considers playing a con.
all the best,
prof



Another Oil Rig Blast

There have been an excess of WTF? moments lately.  Here's yet another:



Coast Guard Reports Blast on Oil Rig in Gulf of Mexico
Filed at 12:17 p.m. ET 9/2/2010

GRAND ISLE, La. (AP) -- An offshore petroleum platform exploded and was burning Thursday in the Gulf of Mexico about 80 miles off the Louisiana coast, west of the site where BP's undersea well spilled after a rig explosion.

The Coast Guard says no one was killed in the blast, which was reported by a commercial helicopter flying over the area Thursday morning. All 13 people aboard the rig have been accounted for, with one injury. The extent of the injury was not known.

Coast Guard Cmdr. Cheri Ben-Iesau said some of those from the rig were spotted in emergency flotation devices.

Seven Coast Guard helicopters, two airplanes and three cutters were dispatched to the scene from New Orleans, Houston and Mobile, Ala., Ben-Iesau said. She said authorities do not know whether oil was leaking from the site.

The Department of Homeland Security said the platform was in about 2,500 feet of water and owned by Mariner Energy of Houston. DHS said it was not producing oil and gas. (continued at New York Times)

Wednesday, September 1, 2010

My Day

It's been a long, hard day.  CRPS, as I experience it most of the time now, comes to me in its Blue Phases -- not *quite* as mesmerizing a thing as Picasso's blues and roses, but remarkable nonetheless.

My Blue Phases are cold, cold, cold -- to touch my legs is to touch ice.  My arms are a pale violet, cool, like evening.

The pain is burning, shooting, stabbing, throbbing -- quite a counterpoint to the cold, cold, cold at the innermost core.

Today, I woke to find both legs involved in a major shift, the left up to the knee, the right about 8 inches above the knee, to mid-thigh.   Red, bright bright, blood red.  Holding your hand inches above the skin, you feel the heat radiate out. 

Lobster red.

Swollen as if pregnant, and not in a fluid-y kind of way.  Solid swollen.  I tried to walk alone to the bathroom and broke down, broke down like a car breaks down, broke down like an insane woman pushed too far breaks down.  Lobster pregnant swollen red red get your red hot here, Edema!


photo courtesy of Practical Neurology

At 9 am, I was already over 100, could feel -- behind the eyes, in the smallsmall joints -- the temperature rising. 

I was fasting before some testing, so I couldn't even indulge in a calming coffee.  Coffee does calm me, and when I am AttackingFever, it gives an extra kick to the Tylenol and ibuprofen.  Or -- I just like coffee, okay?

Today was a first -- I complained about my wait at my MDVIP doc's office.  I was there to donate lots and lots of blood, so that when I go in next week we have an idea of where I am at with these infections, with the systemic inflammation, how my kidneys are holding up, and whether my liver is still unhappy.  I came very close to not going because things were just very very very bad.  Then I remembered that phenomenon common to us all -- the toothache that disappears on the way to the dentist, the sore throat that disappears after you argue your way into an open appointment slot, the car that purrs with perfection after you've lamented its clanking to that very impressive and stern mechanic with the great moustache... Oops.

So I said to myself I said, "Self?"

"Hmmmm?"

"We have to go.  How many times have we wished someone could get a sample of our blood when this Weirdo Weirdo Production goes haywire at 4 am?  Here we are, actually scheduled to go in, with insurance, too -- and we feel like grainy, tasteless applesauce that has been liberally sprinkled with Olde Blackened Wash Water, allowed to cool, and then warmed to lukewarm over a Sterno flame.  Served over a half-cooked shitake mushroom cap that has been oversalted."

So Fred stepped into that Regrettable Role of Loving CareTaker, helped me navigate the Grand Canyon gaping between my wheelchair, curbside, and the bleeping passenger-side seat of Our Ruby, the Honda CRV.  I moaned and cried, I embarrassed myself.

He regaled me with stories about His Girls, the Militant Existential Feminist Lesbians, and their latest shenanigans -- and Fred made the bouncing Ruby fly, as only Ruby can, so that we got there right on time. 

Eighty minutes later, I was writhing.  I writhed.  (Now that's a sentence one never plans on writing!)  And suddenly I decided I was tired of always being the Understanding Patient.  I often get passed over in the wait order -- "because we wanted to clear a special block of time for you";  "because we know you understand how backed up we get";  because, because, because. 

I said to Fred, I said:  "Fred?  Don't they get that it hurts me to have to sit here like this?  I am in effing pain, effing pain," I say!

And Fred, damn him, looks up, coolly, from his second rate novel, and says:  "Apparently not."

So I put the speed on my machine on UberHigh and Zoom over to the receptionist.  I use the Ancient Plain Speech of My People:  "I am having a hard time waiting due to pain.  When can I get back there for a blood draw?"

Unfortunately, she speaks one of the Minor Languages of a Now Extinct Species.  "She said she'd be with you pretty soon, I know I heard her say that.  I think she is waiting to get you into a really good room where you will be most comfortable."

Some things don't translate, as any Foreign Language Teacher will confess to you, if drunk.

Like:  I am here for a blood draw -- you can do it in the hall for all I care.
Like:  I. am. in. pain. So. do. it. Do. it. now.

Alright, yes, there should be kudos for my doc's nurse -- because she is deft and brilliant and the only person who can get my blood without aggravating youknowwhat.   And she is, without doubt, a person of only good intentions. 

Still.  I think I need to dispel this myth that because I am disabled, contorted, and crammed in a chair, sick, that I have no problem spending the day hanging out in a doctor's office.  I am not a piece of furniture.  It happens, to be honest, more at the orthopedic surgeon's office than anywhere else.  They do things like put me in the cast room, "because we know you don't mind waiting..."  Just because I was practically living there, having 7 surgeries in under 18 months, doing either pre-op crap or post-op crap, or what-the-fuck crap... does NOT mean that I do not mind waiting.  Being a frequent flyer by no personal fault shouldn't condemn you to lower standards of hospitality (it's the only word I can think of, but it is not right).

By the time we got home, down the drive, over the moat and beyond the drawbridge... I was almost delirious with fever.

I think I still might be though I have an Annoying Sweat going, that I hope heralds a break in the heat.

Comfort ye, comfort ye, my people. 

This will all have been worth it when we get some illuminating information back from the lab.

Oh. Yeah.  I am way febrile!  When I grabbed the laptop, it was with the intention of directing you, once again, over to Margaret and Helen, that wonderful blog.  Helen Philpot is ranting about the Beck/Palin Revival last week in a post titled 100 Grand Bore.

Allow me to tempt you with its beginning:

Margaret please tell Howard that 100,000 people will show up to a tractor pull if the entry fee is cheap enough. Big deal. I’ll tell you what I’m going to do. I’m going to ignore them and have some pie.

As I see it dear, if more than a hundred thousand dead civilians in Iraq and Afghanistan can be dismissed, so can slightly less than a hundred thousand peckerwoods at a Beck rally.

If the civil rights of millions of gay and lesbian Americans are not important, then neither are the pathetic rants of almost a hundred thousand Palin addicts.


Now, go read the rest!

In other news, there's been yet another meltdown over at Pop That Zit!  This time, it involves a couple of veterans, with one of The New Breed mixed in, for confusion's sake. 

It's funny, and yet not, how a good subset of those who post vids over there decide to confound their own worth with the "value" of their postings.  It's puerile, and says a lot about our messed up notions of "authorship," and... as I have stated a few times, totally BizarroWorld assertions of "ownership."

Well, I am gonna try and convince My Shadow and Near Appendage, Miss Marmy Fluffy Butt, to detach herself momentarily from my dripping side and fetch me some lowfat plain yogurt, mixed with a hint of vanilla, some fine cocoa, a kiss of cinnamon, and 5 packets of fake sugar -- all nicely wisked together.

Then I am gonna imagine myself a balmy lake, and read the rest of this John Irving novel (now I am on A Widow For One Year).

I hope you had a nice day.  If you did not, let's both of us look to tomorrow, with hope.