Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells.
PMID: 23658493 [PubMed] PMCID: PMC3643547
|In the Slammer|
With regard to the recent legal battle between CTTC and a particular message board poster, I thought the following news release would be of interest to this forum.
Seafarer Exploration ( OTC:SFRX ) announced a Hillsborough County Jury rendered a verdict on April 5th 2011 at 4:45 pm in favor of Seafarer for $5,080,000.00 in compensatory damages. After two days of evidence had been presented in court, a jury determined that hundreds of on line posts written by ####### under the screen name of “xxxxxxxx” were false and caused a decrease in market price. Seafarer believes collecting any or all of the damages will be difficult to do, but will continue to try to collect until paid in full. One of the Board Directors for Seafarer, Pelle Ojasu, stated, “We are pleased with the verdict rendered by the jury and I am very happy our CEO maintained his vigilance to prosecute those who would maliciously hurt the Company and its’ personnel through relentless false postings over the last year. Now that the truth has finally come out, we can continue our focus on building shareholder value and executing our business plan.” Lead trial attorney, Craig A. Huffman stated, “Mr. ###### is going to be an example of what should happen to people who sit behind screen names and negatively, falsely, impinge the lives of people and of good companies. We are not done with him yet. This will set a precedent for small market companies to fight back.” Co-counsel, David Chalela, stated, “We and our client are weighing the approach to take toward punitive damages in this case to dissuade others from doing this.”
|Competitive Technologies Inc. CTTC:OTC US|
A randomized, double-blind study of “Scrambler” therapy versus sham for painful chemotherapy-induced peripheral neuropathy (CIPN).
Symptom Management/Supportive Care/Palliative Care
Patient and Survivor Care
2013 ASCO Annual Meeting
J Clin Oncol 31, 2013 (suppl; abstr 9635)
Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2013 Annual Meeting but not presented at the Meeting, can be found online only.
Author(s): Toby Christopher Campbell, Amit J Nimunkar, Janet Retseck, Jens C. Eickhoff, Miroslav Backonja, James F. Cleary, Kristine L Kwekkeboom, Thomas Y Yen; University of Wisconsin Carbone Cancer Center, Madison, WI; University of Wisconsin, Madison, WI; University of Wisconsin Hospitals and Clinics, Madison, WI; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI; University of Wisconsin School of Nursing, Madison, WI; University of Wisconsin Biomedical Engineering, Madison, WI
Background: CIPN is a debilitating, dose-limiting toxicity. The MC5A is a non-invasive electro-analgesia device delivering “Scrambler Therapy,” which has shown benefit for painful CIPN in uncontrolled studies. No sham-controlled trials of MC5A have been performed. Methods: Eligible patients included adults with neuropathic pain (NP) for > 6 months, pain scores =4/10 numerical rating scale (NRS), and no history of diabetes or other peripheral neuropathies. Patients received up to 10 daily sessions of 50 minutes with either MC5A or a novel active sham device constructed to deliver a just perceptible electrical sensation. Sham output is neither a TENS nor MC5A and is designed to be nontherapeutic. Active and sham treatments were applied to the affected limbs. 14 patients were randomized with no baseline differences. Patients and evaluators were blinded to study arm. Pain was measured before, daily during, after and 3 months post-treatment (verbal NRS). The primary endpoint was change in pain. Secondary endpoints included quantitative neurosensory testing (QST), validated patient-report measures, and cytokines. Results: There were 7 patients in each arm. The table shows changes in pain scores pre- and post-treatment by day and group. There was no difference between arms and no arm x day interaction. There was no significant day or arm effect for the function sub scales. Conclusions: In a small pilot study, MC5A was not significantly different from sham therapy for the primary outcome. The sham is feasible and provides a mechanism for future controlled studies with MC5A. Secondary endpoints, e.g. QST are forthcoming. Clinical trial information: NCT01261780.
Nobody will ever need to be shushed in the Bush Libraryby Helen Philpot
Margaret, the next time you go on one of those cruises, you’re just gonna have to take me along because I need a vacation. Fine wine may mellow with age but I sure as hell haven’t. I watched the dedication today for that architectural oxymoron known as the George W. Bush Library. That man was and remains an idiot. In fact, the only one in the family who seems to have any brains at all is the mother, Barbara Bush, who said the country has had enough Bushes’ in the White House. I couldn’t agree more. I hear, however, that she’s a real bitch. That’s certainly alright by me. It takes one to appreciate one.
While watching the dedication I was reminded of his idiocy (I know the human being and fish can coexist peacefully) as well as his arrogance (I am the decider). Lord help me. I wonder if that man’s library even has books. I bet nobody ever has to be ssss-hushed in that place. It’s probably filled with paint-by-number sets.
It just kills me that we put that idiot in office… twice. But I guess there has never been a shortage of idiots in politics.
And speaking of idiots, it seems like every time there is an explosion in the world, Ann Coulter and a bunch of other old white Republican men crawl out of their caves long enough to thump their chests for the cameras. Funny how a bunch of yahoos clinging to the 2nd Amendment after kindergarteners are murdered, suddenly want to throw the rest of the constitution to the curb because this time the culprit was a Muslim using a pressure cooker.... READ THE REST HERE.
Though one hopes these things will reach a natural conclusion, completely market-driven, in this case -- certainly not driven by any sense of moral imperative, or a desire to cleanse both personal and corporate souls of the damning damage being done to desperate people suffering the horrendous pain of CRPS, among other neuropathic conditions -- until they do, we have ourselves, Dear Readers, the opportunity for a series of posts on this moral malignancy of Competitive Technologies and CALMARE.
Dr. Cooney is one of only 10 certified providers of Calmare Pain Therapy Treatment in the U.S. He introduced this treatment for his patients with treatment and medication resistant severe chronic neuropathy and now helps patients from around the country. Dr. Cooney administers every treatment session personally.
At the moment, the only physician in the entire United States who has suckled at the tit of the inventor of the Calmare Magic Poof-the-Pain-Away Crap Technology is one Dr. D'Amato, of Rhode Island (or so I hear, over here in Tête de Hergé, where there is no illness, of course, nor traffic accidents).
Yeah, there *is* a guy opening up 14 pain clinics using the Calmare Magic Poof-the-Pain-Away Crap Technology (Spero Pain Relief Therapy clinics). Guess what? He's an OB/Gyn. Just who I want doing pain management for a central nervous system degenerative disorder.
CTT is the parent company in the USA...and it's now a penny stock. Or almost -- it closed today at 1.70. Because some rubber-stamping idiot approved Calmare Magic Poof-the-Pain-Away Crap Technology as a vendor to the VA, all the devious, deviants, and the hoodwinked are going on and on about how if it's good enough for our Wounded Warriors at the "flagship" Walter Reed (I'm thinking they don't read the Washington Post), then, by gum, it's good enough for you CRPSers!
The Italian inventor was less circumspect, if you can believe it. He claimed that Calmare Magic Poof-the-Pain-Away Crap Technology could reverse aging.
Now you're talking!
Meet, my friends, Giuseppe Marineo, and his explanatory woo and gobbledy-gook from the Italian arm of operations, Delta R&D:
Delta R&D is a bioengineering research centre with a unique history. It was born out of individual research work begun in 1983 by Giuseppe Marineo, a researcher and bioengineer, who advanced theories to reformulate the concept of disease (and the corresponding treatment) from a biophysical rather than biochemical point of view. The idea was to restructure the known features of both according to the principles of thermodynamics by means of an analysis and the detailed specification of the relations between entropy, disease, repair processes and ageing.This new approach to the interpretation of the traditional aspects of medical science makes it possible to go from a highly heuristic system to an extremely conceptual and rationalized system, which can create models of disease and treatment so sophisticated as to render the experimental results highly predictable. If the latter are in line with the predictions they automatically validate the development model.
Furthermore, the very name of the theoretical system developed entails a natural transition from reductionist methods to systems theory which, in the present research, takes the form of a powerful working tool capable of providing adequate support for the development of therapies of practical utility.
In practice Marineo introduced into medical science the research and development criteria typical of engineering, in which the thoroughness of the preliminary theoretical work fully determines the expectations of the experimental verification of the method used. In 1987 the basic research was already sufficiently well structured to be supported by a technology capable of translating the theoretical system into a truly useful therapy.
The first experimental verifications fully confirmed the validity of the theoretical models developed and opened up concrete future prospects for the safe and non-invasive treatment of pathologies for which conventional methods had proved ineffective.
In 1998 the Italian scientific community, which had been constantly informed of all research developments, deemed the product of 15 years research to be scientifically valid, the theoretical principles and experimental data to have been clearly demonstrated and the bioethical principles regarding the respect and protection of the patient to have been respected.
In other words, the research carried out by a private individual was accepted and supported by the public authorities. It was consequently possible to begin official university and hospital studies, at the conclusion of which the first international publications were produced.
In order to support these changes, in May 1998 Delta R&D was set up, thus marking the beginning of the mature stage of this individual research endeavour. Although the original philosophy was retained, a logistical structure was now available to satisfy the new phases of development and to maintain and expand relations with the international scientific community.
In Italy the Delta R&D company became a research centre incorporated into a public structure thanks to the prestigious acknowledgement of the Tor Vergata University of Rome in the form of an agreement in which Delta R&D is recognized as part of the scientific structure of the university while retaining its autonomy and individuality.
Outside Italy, Delta R&D, the theoretical and research work on the Delta-S Entropy Variation Systems and “Scrambler Therapy” pain therapy resulted in Giuseppe Marineo receiving scientific awards for the originality of the basic research, in addition to numerous other acknowledgements by the international scientific community inherent in the acceptance of the proposed published works.
I dunno, maybe that's not your favorite type of woo and gobbledy-gook. How about this? From the lips of Dr. Robert Chalmers, former OB/Gyn:
The treatment is actually quite simple. It involved the machine, wires and surface electrodes that deliver the electrical waveforms. The surface electrodes are the same used in heart monitoring such as an EKG. The patients sits or lies comfortable during each 45 minute treatment session. The electrodes are placed OUTSIDE the area of pain so they will not increase the pain in patients with allodynia from CRPSQ-How does it work?The mechanism is completely unique. The primary issue with CPRS is the so called physiologic "wind-up" in the brain. This is a complicated change in the nervous system and can be traced at least in part to changes in NMDA receptors in the brain. We need to get to the brain to help with this disease. The use of electricity for the management of pain is not unique to the Calmare system and I am sure many RSD sufferers have tried traditional TENS therapy. However, the Calmare system is not anything like a TENS unit. Injury or other noxious stimulus in the body creates pain chemicals. These chemicals in turn get converted into electrical impulses by your nerves which get transmitted to the brain and get INTERPRETED by the brain. When we use the Calmare system we "control" the electrical impulses that the brain is recieving. By manipulating the input into the brain we "convince" the brain that the area of the body where pain was present is now normal. We know that the brain can be taught, in medicine we refer to thoses changes as Neuroplasticity and there is quite a bit of interesting reading on that topic on the internet if you have the time. I was the worlds biggest cynic prior to actually treating patients with the machine. I thought it was TENS or Placebo but nearly every patient I have treated has already tried TENS therapy and they can tell you this is nothing like TENS.It works!
…oh, lordy!…what walks like a scam and goes “scam, scam, scam”?…you get three guesses and one hint — its initials are “CTT”…their idiotic “Calmare device” is NOTHING more than a TENS device…and just like a TENS device, the extent to which it works depends ONLY on whether the doctor can con the patient into believing that it actually IS doing something — which, other than making a muscle twitch now and then — it doesn’t…you can even see it in CTT’s description:
“The method incorporates electromedical equipment for electronic nerve stimulation, and uses the nerve fiber as a passive means to convey a message of normality to the central nervous system (CNS) by a procedure defined as scrambling or tricking of information, which then enables the CNS to modify the reflex adaptive responses – referred to as TEMPR – Transcutaneous Electrical Modulation Pain Reprocessor.”
…have you ever heard such a line of malarkey in your life?…how on earth can a nerve transmit a message by a “passive means”?…that sentence is nothing more than gobbledygook meant to sound impressive…an even better example of obfuscation:
“The assumed pre-coding capacity is a more logical explanation than stochastic fluctuation (which in this case must be re-interpreted as a consistent modification of the information content per stimulus/time) the different discharge time characteristic used by the receptor for the same stimulus if this occurs in sufficiently short time intervals. In this perspective, to return to our model, the comparator?? Is the arbitrary module that sorts the information, compares it with a short-term memory and if it recognizes a stimulus similar to the preceding one, modifies the gain data and the information property which it passes on to the amplifier/attenuator (synapsis), a vital element that controls the passage/non passage of the “decoded” information stripped of spurious signals, associating it with the correct degree of intensity. Again with reference to the model, the noise and stochastic variations are separated since, in my analysis, at least some of these fluctuations actually consist of sub-information capable of modifying the learning capacity and sensitivity to the stimulus if repeated over short time intervals. If the data are reinterpreted in this sense, frequency modulated discharge sequences immediately took on a different significance when combined with the “pseudo-noise” modulation accompanying them and which became an essential element of the “primary” information. At this stage I considered that I had all the elements required to materially construct a pain scrambler (technically an information mixer), that is, a system capable of “masking” the pain signal.”
…that came from Marineo’s website:
…don’t strain too hard trying to understand that since it’s little more than confabulation…but do read at least the other pages about how he can cure cirrhosis, remove scars and reverse aging using his “entropy variation system Delta S”:
…and if THAT doesn’t convince you the guy is a goofball, then consider his “technowind” :
http://www.deltard.com/eng/tecnowind.php…a “limited edition” and “autographed” FAN!…I mean, where did CTT find this character?…come’on!…wake up and smell the scam!…do your readers a favor and don’t pump idiotic quack devices…May 26, 2010 9:06 am
|PHOTO BY SCOTT LONDON|
is he not, at this moment, the most beautiful man in the world?
|well, okay, this is a little along the lines of "find your happy place and let roots grow out your ass, |
reaching down to the rich loam of the earth" but it's tuesday and we've all got to get to wednesday, and so on
and so forth. i once paind a woman $350 dollars to wave sage over my body and make a crystal bowl sing.
i had wine glasses which, if filled with a good wine, would have sung better, and cigarettes,
which would have smelled better and not made me cough.
|dr. seuss is god-like. in tête de hergé? he is god.|
|i dunno. do you?|
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