Showing posts with label Money-Grubbing Bastards. Show all posts
Showing posts with label Money-Grubbing Bastards. Show all posts

Monday, July 6, 2009

Anacoluthe!

"Billions of bilious blue blistering barnacles in a thundering typhoon! Subtropical sea-louse! " I stared, enthralled, at her pink sweaty face while La Belle et Bonne Bianca Castafiore paused to take a breath.

"Swine! "


That apparently exhausted her reserve of beloved Captain Haddock exhortations in English, for the next thing I knew, she was belting them out in French:


"Perroquet bavard! Sale menteur!
Anacoluthe!
Analphabète!"

Clearly, she enjoys the alliteration in English, and the vagaries of a lost insult in French.

Vagaries? Maybe to us... mais pour le capitaine Haddock? No, he was schooled by Tête de Hergé himself! "Anacoluthe"? Nothing but a blurt-out? Not hardly, as the kids say.

The Blessed Wikipedia explains:

An anacoluthon is a rhetorical device that can be loosely defined as a change of syntax within a sentence. More specifically, anacoluthons (or "anacolutha") are created when a sentence abruptly changes from one structure to another. Grammatically, anacoluthon is an error; however, in rhetoric it is a figure that shows excitement, confusion, or laziness. In poetics it is sometimes used in dramatic monologues and in verse drama. In prose, anacoluthon is often used in stream of consciousness writing, such as that of James Joyce, because it is characteristic of informal human thought.

In its most restrictive meaning, anacoluthon requires that the introductory elements of a sentence lack a proper object or complement. For example, if the beginning of a sentence sets up a subject and verb, but then the sentence changes its structure so that no direct object is given, the result is anacoluthon. Essentially, it requires a change of subject or verb from the stated to an implied term. The sentence must be "without completion" (literally what "anacoluthon" means). A sentence that lacks a head, that supplies instead the complement or object without subject, is anapodoton.

And "analphabète"? Well, that's just pee-in-your-pants funny. Ah, but the poor dear was not in a joshing mood, all pink and sweaty, her violet-besotten frock-and-sash a muddled mess. Still, even at such a moment, Bianca is one of the few women whose strong calf muscles will always nicely set off a red pointy-toed stiletto pump. Such natural gifts, in fact, are divine appointments of grace in this anxiety-driven, pain-filled world of ours.

You see, la Belle et Bonne Bianca Castafiore had just been pulled over by the cops --a mere kilomètre from Marlinspike Hall, the warm hearth of home -- and given two tickets and a summons to appear on August 12. Before I could express both my wrath that she was driving my darling Ruby to begin with, and my pleasure that, whatever the circumstances, both she and Ruby were apparently unharmed, the Dastardly Diva exclaimed:

"Et c'est tout à fait de ta faute, toi! And it is all your fault!"

My eyes narrowed in suspicion. "Comment ça?"

It turns out that she would never have forgotten to renew her driver's license if I had not been such a distraction, with all my drama, fever, infection and such. When I pointed out that she had been absent for a good period of the "drama," and was not overly concerned when she actually had been at The Manor, she looked me square in the eye, and... sniffed.

There was a brief lull during which either one of us might have chosen the higher way and opted to be the better person.

"The only reason le flic nabbed me for speeding was that I was practicing getting you from zee Manor to zee 'opital in whatisityoucall? Ah, yes! Zee no time flat! Comme je t'ai dit, tout, tout, tout -- c'est tout à fait de ta faute!"

This may have been when I felt compelled to make a few observations relating to personal and communal responsibilities, perhaps even a remark or two on hygiene -- I don't sniffin' remember.

Even though I had promised the more levelheaded Fredster not to make mention of it, I found myself, in my best scary voice, relating how, on a frigid, late-spring, early afternoon during one of her lighthearted jaunts around Europe, icicles were glinting on the Marlinspike's eaves -- and the alluring scent of two putrid cans of half-eaten Libby's Vienna Sausage* stuffed in the serpentine bottom drawer of a 16th century French armoire -- beautifully restored as a well-stocked wet bar -- led Fred and me, on behalf of our spry-tongued seafaring benefactor (and hers) -- the good Captain Haddock -- to jimmy the lock of her appartement. {don't touch my paragraph}

Slowly she turned... her BB-gun pupils a steely grey -- "Yes? Ah. Oui?"

"Yes," I continued, "we have been inside. We have seen it with our own eyes, and we are shocked, Castafiore, shocked! Whatever could you have been thinking? What will our spry-tongued seafaring benefactor conclude when he hears about this abomination, this perversion of his family's ancestral home?"

La Belle et Bonne Bianca hung her head. Without looking up, in a steady voice, sounding well-practiced, she recounted the story of Her Fall, beginning with the unthinkable -- how the Faust of Gounod had finally, and for the first time, had a closing night -- and how all those arty Anglophiles were rubbing it in with glee: The Mousetrap wins; It has never stopped running since its premier at London's Ambassador’s Theatre in 1952.

There would be no more "je ris de me voir si belle dans ce miroir" until the financial wizards of the world managed to staunch the bleeding that was hemorrhaging the bottom lines of the operatic universe.

The Castafiore, out of work and desperate to continue to earn a living, fell back on her early training as itinerant seamstress to the Wandering Renaissance Reenactors of Belgium, and, unexpectedly, Wales. All that time we assumed that she was touring Faust -- and okay, yes, I was a tad bit self-absorbed with the cartography of my own navel.

Still. Still! "Bianca... How? Where did you get the money?"

"I borrowed it, it was easy. I borrow, then I borrow again, at a better rate, and swap-switch the debt. You know -- take from Peter and give to Paul and, above all, keep washing the Messiah's feet -- no one ever takes a close look at the beautiful chica whose long hair and boobies are all hanging out..." said my friend, her bitterness spilling over. "I just wanted to be able to send money back to my familia rustica, trapped down on the farms outside Roma. Is that so wrong?"

"You really have a flair, you know. If I did not know quite a bit about Chenonceau, I might have fallen for it. I mean, really, Castafiore! How much were you going to charge?"

"That is the trick, mon amie. I would ask 'only for what you can spare, to defray the costs of upkeep.' The tourists? They would squirm in guilt, they would take out their portefeuilles and fill the coffers with their monies. After all, Francois Ier is the epitome of the Renaissance... and toss about the story of Leonardo da Vinci having died in his arms, cared for during his final days in the King's own bed chamber." Her eyes were glowing; She was far away.

She and her unemployed theatre cohorts got it in their minds to gut the Captain's appartement and build a replica of Francois Ier's bedroom at Chenonceau. Never mind how confused her explanations could get in an attempt to distinguish his digs at Chenonceau from the official residence at Château de Blois, and how they managed to confuse the one with the other in her imaginary trip down the Loire Valley.

And how was she going to get people in and out of the place without stirring, umm, lots of suspicion? Easy... cut a door through the three feet of stone leading to that nice shady spot at the northern end of the moat.

We never would have seen or heard a thing.

Hard times... they surely do bring something out of people. We sat and stared at one another -- me, determined to never complain again, because that risks causing people to be carted off to jail, so abstracted are they by my constant grief, and The Castafiore? Sorry mostly at having been caught, but also regretting the end to subterfuge, she was thinking of all those nice doublets waiting to be sown and beaded at 600 Euros a pop.




*"Vienna sausages are life’s 'fuck you' waiting in the cabinet when you’re hung over and depressed..."

Wednesday, June 3, 2009

toujours, ce sacré miroir (et moi, là-dedans...)

I don't know what I am doing with this blog anymore.

Honestly, I'm not fit for human company. Unwashed, in the same clothes I wore yesterday -- I hurt so badly last night that washing and changing were unimportant. Sleep mattered, that was it. Even so, sleep came in spurts of 45 minutes. She's down! She's up!

La Bonne et Belle Bianca Castafiore gave me a look of pure disdain this morning. "Que t'es bête, prof... complètement bête."

To her, it is a matter of will, getting better, an area in which I am found sorely lacking. The fact that there are ungrowable pathogens destroying my bones, and apparently getting into some soft tissue (one side of my face is swollen, to the point where I have a permanent headache and my glasses are digging into the side of my head)? Not pertinent to The Castafiore.

Will it all away.

She is something of a changed woman these days -- being an out-of-work Diva has been both a curse and a strange blessing. Fred and I admit to appreciating the decline in the ear-splitting frequency of L'Air des Bijoux, and that blessed mirror, that laugh approaching hysteria.

You see, Bianca only sings L'Air des Bijoux from Gounod's Faust.

Not that this is at all out of the ordinary, an operatic star fixated on one role, one lyric, one composer. We all can get stuck on our favorite things, certainly on a cherished ditty. But..."Ah, je ris de me voir si belle, dans ce miroir..." -- ad infinitem? ad nauseum? I want to reach through the time and space of fiction to shake that stupid Marguerite, to point out the obvious devil traits before her in the unctuous Faust, all in the hope of getting La Bonne et Belle Bianca, the Milanese Nightingale, to shut up!

So she thinks I am an idiot. I can take it. She has called me worse things, in the middle of some madcap caper or other, usually seeking the approval of Captain Haddock -- what better way than to throw the extraneous French professor under the bus?

Feels like I've nowhere but *here* to emote; My thoughts are hardly worth noting anymore -- repetitive tripe.

I am spending the day making and fielding phone calls from doctors' offices. Now that there is a workable plan to put in place, there's nothing much for me to do except fret. And I am almost too tired and in too much pain to do that.

The current task is the assemblage of medical records that I am to hand carry to this guru of a medicine man, a mere half-day's drive from Marlinspike Hall, deep deep in the Tête de Hergé.

Ah... a wrinkle. Yes just in the space between the last paragraph and this. My MDVIP Go-To-Guy called to say I will likely see the Wizard next Tuesday. He paused and then regaled me with the heartwarming story of how, seeing that the Wizard-Guru Man has just relocated here from Ohio, he's not had time to establish his insurance connections. "That might be a problem for you," opines my Go-To-Guy. Bull Crap Bull Skeet of Tête de Hergé is an imposing monolith of a health insurer, indeed.

YOU THINK? GAWD...

Am I so sick that I am supposed to be able to magically bankroll this consultation? I have spent over $20,000 thus far this year on health care -- and that money came straight out of my investment account, the account that was not to be touched because it will hopefully, one day, have enough in it to comfort, shelter, and feed The Fredster and The Castafiore, as well as the Four Felines. It was never meant to be money spent on BCBS, hospitals, doctors, repeatedly unhelpful tests, and month after month of intravenous vancomycin...

That money was supposed to survive me, god damn it.

ah... je ris... je ris... de me voir... si bête, si bête... toujours dans ce sacré miroir...

The expert we are consulting doesn't even have an established surgical team, barely an office -- he is a new prof at the medical college there. Yonder. One of the administrators is going to attempt to get his provider numbers with Bull Crap Bull Skeet of Tête de Hergé tomorrow.

But everyone knows my situation vis-à-vis the paddle and the creek -- so I may have to write a magic check.

Friday, March 20, 2009

Follow the Money: Scott Reuben, MD

Scott S. Reuben, MD.

Amazingly, I actually knew who he was before the news of his many years of academic fraud recently broke. There are not many authoritative researchers in the field of pain management, in general, and even fewer who further subspecialize in the treatment of CRPS/RSD.

Pain management doctors (most being anesthesiologists), physiatrists, and neurologists all probably refer to his "work" as justification for refusing to treat CRPS pain with opiates, opting instead for some "multimodal" (Dr. Reuben's buzz word) combinations that usually included Lyrica and anti-depressants.

Sad to say, he has "made" Wikipedia due to infamy rather than achievement.

His fabricated results date back to 1996 and did not actually perform *any* of the clinical trials upon which his voluble opinions were based. Colleagues and fellow researchers struggle to understand the reasons for this incredible case of academic dishonesty, named "misconduct"; Really, though, if investigators "follow the money," I am sure Dr. Reuben's reasons will become as clear as they are commonplace to most criminal activity.

One possible avenue of investigation springs readily to mind:



A cornerstone of Dr. Reuben’s approach has been the use of the selective
cyclooxygenase-2 inhibitor celecoxib (Celebrex) and the neuropathic pain agent
pregabalin (Lyrica), both manufactured by Pfizer. Dr. Reuben has received
research grants from the company and is a member of its speakers’ bureau.
However, a source told Anesthesiology News that Pfizer recently alerted its
speakers to remove any reference to Dr. Reuben’s data from their presentations.
Pfizer was unable to comment by the time this article went to press. The company
has not been accused of wrongdoing in the matter.


The extent of his fraud is hard to comprehend. He published influential research for 12 years about clinical trials that he never conducted. (I know I am repeating myself. It is just almost impossible to believe. How did he do it? He cannot have done this alone. Could he?) Decisions about anesthesia protocol and trends in treatment of chronic pain syndromes were based on his "work." He seems to have targeted the orthopedic community above others -- are OS less likely than others to look under rocks, to question the validity of research? I think not! Maybe it is simply that chronic pain is a common result after orthopedic surgery -- from osteoarthritis to CRPS -- and, like any surgery, a short period of acute pain is virtually guaranteed. And since he was purportedly conducting clinical trials, orthopedics would offer a good sized cohort of patients having similar surgeries -- anterior cruciate ligament repairs and other knee surgeries seemed to his liking, as well as amputations and spinal fusions.

In addition to Lyrica and Celebrex, Reuben was pushing Bextra, Effexor, and Vioxx:

The hospital has asked the journals to retract the studies, which reported favorable results from painkillers including Pfizer Inc.'s Bextra, Celebrex and Lyrica and Merck & Co. Inc.'s Vioxx. His studies also claimed Wyeth's antidepressant Effexor could be used as a painkiller. Pfizer gave Reuben five research grants between 2002 and 2007. He was a paid member of the company's speakers bureau, giving talks about Pfizer drugs to colleagues. Reuben also wrote to the Food and Drug Administration, urging the agency not to restrict the use of many of the painkillers he studied, citing his own data on their safety and effectiveness. "Doctors have been using (his) findings very widely," said Dr. Steven Shafer, editor of Anesthesia and Analgesia, a scientific journal that published ten articles identified as containing fraudulent data. "His findings had a huge impact on the field." Paul White, another editor at the journal, estimates that Reuben's studies led to the sale of billions of dollars worth of the potentially dangerous drugs known as COX2 inhibitors, Pfizer's Celebrex and Merck's Vioxx, for applications whose therapeutic benefits are now in question.


This biographic blurb describing Dr. Reuben and his work is frightening to read, knowing the truth:


Scott S. Reuben, MD is Director of the Acute Pain Service and Professor of
Anesthesiology and Pain Medicine at Baystate Medical Center and the Tufts
University School. He performed his anesthesia residency and fellowship in pain
management and regional anesthesia at Mount Sinai Medical Center in New York.
Dr. Reuben has authored over 100 articles and dozens of abstracts in peer reviewed anesthesia, pain medicine, surgery, and orthopedic journals. He has presented his papers and lectured at both the national and international level
speaking on all items of interest for the pain management practitioners and scientists, including acute pain management, pre-emptive analgesia, and the use
of various analgesics to manage pain. Dr. Reuben has served as an advisory board
member for the JCAHO, ASA Task Force for Acute Pain Management, and currently serves as a journal reviewer for Anesthesiology, Anesthesia & Analgesia,
Journal of Pain and Symptom Management, Journal of Clinical Anesthesia, Journal of Bone and Joint Surgery, Arthroscopy, Journal of Pharmacology and Therapeutics, and Lancet. In June of 2007 he authored the Current Concepts Review article in the Journal of Bone and Joint Surgery.
Advisor to JCAHO!

Journal reviewer!

Author of Current Concepts Review!

In a field where one hopes that reproduction of results -- basic to scientific method -- holds sway, how is it that these fictions were allowed to circulate and be emulated for so long? "Peer review" certainly should not be the sole arbiter of validity. Essentially, Reuben's work was rubberstamped by his "peers," or else he served as his own judge, and we see how well that worked out...

How to accurately quantify the amount of pain this man has caused? How many "adverse reactions," how much permanent impairment, how many deaths?

Sunday, December 21, 2008

Wordle Challenge Rewards

As of yet, there have been no attempts to solve any of the three outstanding Wordle Challenges. [Update -- Challenge #1 was handily elucidated as being the opening line to Joyce's Ulysses.]

Then it occured to me: "Perhaps contestants are awaiting notification of their potential winnings, those money-grubbing bastards!"

Rewards will be as stratified as the challenges themselves, which range from "easy" to "difficult." Should you successfully rearrange a citation and give the correct attribution, in addition to being WordleMeister of the Day,
you win:



Wordle Challenges #1 and #2 (Easy) --
a used copy* of the work in question;
Wordle Challenge #3 (Difficult) -- a used copy* of the work in question AND A Never Before Issued, One-of-a-Kind Commendation.

*Books will likely be obtained via Half.com and, therefore, sent to you by a third party. If you're of an altruistic bent, you can forego your winnings -- and the book in question will be sent, second day air, to the starving child of your choice.