Thursday, February 14, 2013

CRPS Open Access Article: BMC Neurology

Hooray, once again, for Open Access research articles from BMC Neurology.  In this instance, it's another well done bit of research that points toward... the inflammatory process. Surprise!

I'm only reproducing here the abstract and author information, so that you can decide if you'd like to pour yourself a cup or a glass of something and peruse the longer, very technical article.  This one is definitely beyond me, but there is always information to be gleaned, learning to be done.

Do you hear it?  "Tomorrow, tomorrow..." is playing somewhere nearby.  Well, I'll just crank up some Bonnie Raitt.

I'm on a Bonnie Raitt kick.

Okay, back to business.  First, a word about BMC Neurology and its publication policies:

BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology. 
It is journal policy to publish work deemed by peer reviewers to be a coherent and sound addition to scientific knowledge and to put less emphasis on interest levels, provided that the research constitutes a useful contribution to the field.

They have, as I said, an open-access policy to most research, as well as a freely accessible database of case reports.  It's an enlightened approach and one much appreciated by individuals and families/friends attempting to research illnesses and who are at times desperate for information that normally must be purchased on the basis of a short abstract teaser.  Just in case it hasn't sunk in yet, or you are just coming out of shock:

Open access 
All articles published by BMC Neurology are made freely and permanently accessible online immediately upon publication, without subscription charges or registration barriers... 
Authors of articles published in BMC Neurology are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement.

Clearly, money must change hands at some point, and this is accomplished by a system of "article-processing charges," bless their souls.  Note, however, that:  "We routinely waive charges for authors from low-income countries."

There is still time to send a Valentine!

The CRPS / RSD article in question is:

Morphological macrovascular alterations in complex regional pain syndrome type I demonstrated by increased intima-media thickness
BMC Neurology 2013, 13:14
Nicola Derenthal1Tim Maecken2Elena Krumova1,4Alfried Germing3 andChristoph Maier1*

Although intima-media thickness (IMT) was increased in several inflammatory diseases, studies investigating whether the inflammatory processes lead to macrovascular alteration with increased IMT in complex regional pain syndrome (CRPS) lack.

Well. Blogger HTML dislikes the Methods and Results sections of the Abstract because they come too close, in their statistical formulations, to HTML code.  Good thing this is an OPEN ACCESS research article, eh?


The increased IMT of peripheral arteries in CRPS suggests ongoing inflammatory process. Until now, only endothelial dysfunction has been reported. The presented morphological macrovascular alterations might explain the treatment resistance of some CRPS patients.

The electronic version of this article is the complete one and can be found online at:
Received: 14 September 2012
Accepted: 3 February 2013
Published: 6 February 2013

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